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    best time of day to take zoloft. What is best time of day to take zoloft? best time of day to take. If Zoloft makes you tired, take it at night. If it makes you wired, take it in the morning. As long as you take it at the same time every does anyone take or have taken Zoloft? thinlissy. Sep 15 2007 14:14.. I only had time to work out once a day for 30 minutes which for me, is not enough.. Try to take the medicine

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